Journal of Research in Medical Sciences
Volume:28 Issue: 7, Jul 2023

The shape of the left ventricle (LV) is an important index to explore cardiac pathophysiology. A comparison was provided to estimate circumferential, longitudinal, and radial wall stress in LV based on the thick?walled ellipsoidal modelsof Mirsky and Ghista?Sandler for discriminating significant coronary artery disease (CAD) patients from no CAD patients.

According to the angiography findings, 82 patients with CAD were divided into two groups: 25 patients without significant CAD and 57 patients with significant CAD of single vessel and multivessel. An ellipsoidal LV geometry was used to calculate end?systolic passive stress as the mechanical behavior of LV. Echocardiographic views?based measurements of LV diameters used to estimate the end?systolic wall stress.

Circumferential wall stress between the control group and significant CAD groups was significantly elevated for the Ghista model (P = 0.008); also, radial and longitudinal stress of the multi?vessel CAD group was significantly higher than the control group (P = 0.01 and P = 0.005, respectively). All stress parameters of the multi?vessel CAD group were statistically significant compared to the control group for the Mirsky model. Receiver operating characteristics curve analysis was shown the circumferential stress of multi?vessel CAD with an area under the curve (AUC) of 0.736 for the Ghista model and an AUC of 0.742 for the Mirsky model.

These results indicated that Ghista and Mirsky model estimates ofcircumferential passive stress were the potential biomechanical markers to predict patients with multi?vessel CAD. It could be a noninvasive and helpful tool to quantify the contractility of LV.

Sirolimus is a potent immunosuppressive in renal transplantation. However, its use is limited by some reported side effects. The objective of this study was to determine the side effect profile of sirolimus in renal transplant patients.

In the present study, we retrospectively reviewed the medical records of 116 renal transplant patients treated with sirolimus alone or in combination with other immunosuppressive agents at private therapeutic centers in Isfahan, Iran, between March 2009 and February 2020. A checklist was used to collect data on demographic and clinical variables. Data were analyzed with independent samples t?test and Chi?squared test.

Our findings indicated that the most prevalent sirolimus?related side effects were edema (42.3%), proteinuria (37.5%), cytopenia (26.9%), abnormal level of liver enzymes (11.7%), and pneumonitis (9.7%). Stratification of side effects by sirolimus dose (<2 mg and ?2 mg) demonstrated their dose?independentoccurrence (P > 0.05). Pneumonitis was the most frequent reason for sirolimus cessation (58.7%). No significant differences were observed between males and females regarding the frequency of reasons for sirolimus cessation (P > 0.05).

Edema, proteinuria, cytopenia, abnormal level of liver enzymes, and pneumonitis were the most prevalent sirolimus?related side effects in renal transplant patients. Further prospective cohort studies are warranted to detect underlying mechanisms and determinants of these side effects in renal transplant patients treated with sirolimus.

Despite a lot of efforts made in the rabies health?care system, Iran is still in an endemic region and millions are spent annually to prevent rabies.

Searching in national and international databases has been performed. The preferred reporting items for systematic reviews and meta?analyses protocol were followed. To assess heterogeneity, the I?index wascalculated. In addition, sensitivity analysis was performed by the remove?one method. The publication bias was also investigated by Egger’s regression test, and the trim and fill method. To perform a meta?analysis, CMA version 2 software was used.

Totally, 33 studies with 250,980 animal?bite cases were meta?analyzed. A summary estimate of the incidence of 1200 per 100,000 population (95% CI 1000, 1500) with a mean age of 29.97±15.13years (95%CI: 29.33, 30.61) was estimated. The rate in men was higher 76.7% (95%CI 74.7%, 78.8%) than in women and in the rural 49.7% (95%CI: 42.8%, 58.6%) was equal in the urban. Most bites occurred in the spring and summer 20.5% (95%CI: 16.1%, 25.9%). The highest of job-related bites was in students 20.1% (95%CI: 19%, 23%). The highest rate of bite location and the animal type were estimated in the order of lower limbs and by dogs respectively. The rate of complete vaccination 61% (95%CI: 43%, 76%) and immunoglobulin injection 39% (95%CI: 22%, 59%), were estimated respectively.

Estimates reveal that there has been little change in the animal bites over the years. It is necessary to take special actions to control the disease at the national and international levels.